کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007629 1066381 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Animals models of MCH function and what they can tell us about its role in energy balance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Animals models of MCH function and what they can tell us about its role in energy balance
چکیده انگلیسی

Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy expenditure in rodent models, and the central sites where MCH acts in regulating energy homeostasis. Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 30, Issue 11, November 2009, Pages 2040–2044
نویسندگان
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