کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007774 1066386 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using reduced amino acid composition to predict defensin family and subfamily: Integrating similarity measure and structural alphabet
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Using reduced amino acid composition to predict defensin family and subfamily: Integrating similarity measure and structural alphabet
چکیده انگلیسی

Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information and insights for the basic research of defensins. In this study, by selecting the N-peptide composition of reduced amino acid alphabet (RAAA) obtained from structural alphabet named Protein Blocks as the feature parameters, the increment of diversity (ID) is firstly developed to predict defensins family and subfamily. The jackknife test based on 2-peptide composition of reduced amino acid alphabet (RAAA) with 13 reduced amino acids shows that the overall accuracy of prediction are 91.36% for defensin family, and 94.21% for defensin subfamily. The results indicate that ID_RAAA is a simple and efficient prediction method for defensin peptides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 30, Issue 10, October 2009, Pages 1788–1793
نویسندگان
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