کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007908 1066389 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioactive analogs of neurotensin: Focus on CNS effects
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Bioactive analogs of neurotensin: Focus on CNS effects
چکیده انگلیسی

Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract. It is closely associated anatomically with dopaminergic and other neurotransmitter systems, and evidence supports a role for NT agonists in the treatment of various neuropsychiatric disorders. However, NT is readily degraded by peptidases, so there is much interest in the development of stable NT agonists, that can be injected systemically, cross the blood–brain barrier (BBB), yet retains the pharmacological characteristics of native NT for therapeutic use in the treatment of diseases such as schizophrenia, Parkinson's disease and addiction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 10, October 2006, Pages 2523–2533
نویسندگان
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