کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2008015 | 1066393 | 2007 | 7 صفحه PDF | دانلود رایگان |
We investigated the role of kinin receptors in cardiac remodeling after ischemia/reperfusion (I/R). Bradykinin injection improved cardiac contractility, diastolic function, reduced infarct size and prevented left ventricular thinning after I/R, whereas des-Arg9-BK injection had no protective effects. Bradykinin, but not des-Arg9-BK, reduced cardiomyocyte apoptosis and increased Akt and GSK-3β phosphorylation. Furthermore, myocardial infarct size was similar between wild type and B2 knockout mice after I/R, but significantly reduced in kinin B1 receptor knockout mice. These results indicate that the kinin B2 receptor, but not the B1 receptor, protects against I/R-induced cardiac dysfunction by inhibiting apoptosis and limiting ventricular remodeling.
Journal: Peptides - Volume 28, Issue 7, July 2007, Pages 1383–1389