کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008058 1066395 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression
چکیده انگلیسی

Central administration of both CART and GLP-1 reduces feeding and increases c-Fos in brain areas associated with food intake. To determine whether aspects of CART's effects were mediated through GLP-1's action, we examined whether the GLP-1 receptor antagonist des-His1-Glu9-exendin-4 (EX) blocked CART-induced feeding inhibition, and c-Fos activation. An i.c.v. dose of 100 μg EX blocked the feeding inhibitory action of 1 μg of CART i.c.v. and prevented CART-induced c-Fos expression at multiple hindbrain and hypothalamic sites. These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 1, January 2006, Pages 157–164
نویسندگان
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