کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2008197 | 1066400 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The regulation of α-MSH release by GABA is mediated by a chloride-dependent [Ca2+]c increase in frog melanotrope cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The regulation of α-MSH release by GABA is mediated by a chloride-dependent [Ca2+]c increase in frog melanotrope cells The regulation of α-MSH release by GABA is mediated by a chloride-dependent [Ca2+]c increase in frog melanotrope cells](/preview/png/2008197.png)
چکیده انگلیسی
In frog melanotrope cells, γ-aminobutyric acid (GABA) induces a biphasic effect, i.e. a transient stimulation followed by a more sustained inhibition of α-MSH release, and both phases of the GABA effect are mediated by GABAA receptors. We have previously shown that the stimulatory phase evoked by GABAA receptor agonists can be accounted for by calcium entry. In the present study, we have investigated the involvement of the chloride flux on GABA-induced [Ca2+]c increase and α-MSH release. We show that GABA evokes a concentration-dependent [Ca2+]c rise through specific activation of the GABAA receptor. The GABA-induced [Ca2+]c increase results from opening of voltage-activated L- and N-type calcium channels, and sodium channels. Variations of the extracellular Clâ concentration revealed that GABA-induced [Ca2+]c rise and α-MSH release both depend on the Clâ flux direction and driving force. These observations suggest for the first time that GABA-gated Clâ efflux provokes an increase in [Ca2+]c increase that is responsible for hormone secretion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 10, October 2005, Pages 1936-1943
Journal: Peptides - Volume 26, Issue 10, October 2005, Pages 1936-1943
نویسندگان
Laurence Desrues, Hélène Castel, Maria M. Malagon, Hubert Vaudry, Marie-Christine Tonon,