کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2008315 | 1066406 | 2006 | 4 صفحه PDF | دانلود رایگان |

Although many potential pathways exist for the prebiotic condensation of amino acids to form simple peptides, minimal conditions for such a reaction in the dry state have yet to be defined. In this work, water was evaporated from a solution of alanine and copper chloride (CuCl2), creating a dry residue. Incubation of this residue at moderate temperatures over 25 days produced even greater amounts of di-alanine, as determined by high performance liquid chromatographic characterization of the re-dissolved residue. Copper(II) and chloride were required for the reaction and di-peptide yields were highest for 1:2 molar ratios of copper:alanine. These results define minimal conditions for a dry-state pathway that plausibly played a role in the prebiotic formation of simple peptides.
Journal: Peptides - Volume 27, Issue 4, April 2006, Pages 607–610