کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2008398 | 1066411 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R) The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)](/preview/png/2008398.png)
چکیده انگلیسی
High levels of binding sites for melanocortin peptides exist within the arcuate nucleus, and a functional response to melanocortin peptides has been demonstrated in arcuate POMC neurons. Because the MC3R is thought to function as an inhibitory autoreceptor on POMC neurons, we reasoned that peripheral injections of MC3R-specific agonists would act within the arcuate nucleus to inhibit POMC neurons and thereby stimulate feeding. We demonstrate that the peptidergic MC3R agonist, d-Trp8-γ-MSH, stimulates feeding via the MC3R when injected peripherally. These data provide the first evidence that feeding can be stimulated by peripheral injection of MC3R-specific agonists.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 2, February 2006, Pages 259–264
Journal: Peptides - Volume 27, Issue 2, February 2006, Pages 259–264
نویسندگان
Daniel L. Marks, Victor Hruby, Gregor Brookhart, Roger D. Cone,