کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2008420 | 1066411 | 2006 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins](/preview/png/2008420.png)
چکیده انگلیسی
Phylogenetic, developmental, anatomic, and stimulus-specific variations in post-translational processing of POMC are well established. For melanocortins, the role of α-N-acetylation and the selective activities of α, β, and γ forms are of special interest. Acetylation may shift the predominant activity of POMC products between endorphinergic and melanocortinergic actions—which are often in opposition. This review addresses: (1) variations in POMC processing; (2) the influence of acetylation on the functional activity of α-MSH; (3) state- and stimulus-dependent effects on the proportional distribution of forms of melanocortins and endorphins; (4) divergent effects of α-MSH and β-endorphin administration; (5) potential roles of β- and γ-MSH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 2, February 2006, Pages 453–471
Journal: Peptides - Volume 27, Issue 2, February 2006, Pages 453–471
نویسندگان
Charles W. Wilkinson,