کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008459 1066415 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology
چکیده انگلیسی
VIP and PACAP impact strongly on human pathophysiology. Their receptors are very promising targets for developing new drugs in the treatment of inflammatory and neurodegenerative diseases. This article reviews the present knowledge regarding VIP and PACAP receptors, i.e. VPAC1, VPAC2 and PAC1. This includes: (I) a critical review of instrumental peptide agonists and antagonists; (II) a survey of recent data regarding the structure of VPAC1 receptor and the docking of VIP in the receptor binding domain. Structural models for the VPAC2 and PAC1 receptor N-terminal ectodomains are also described; (III) A critical description of the two models of VPAC1 receptor activation in the general context of class II/family B G protein-coupled receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 28, Issue 9, September 2007, Pages 1631-1639
نویسندگان
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