کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008528 1066422 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancy
چکیده انگلیسی

Significant ethnic disparities exist in reproductive outcomes. A potential contributing factor may be the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and placenta during pregnancy. In the present study, levels of cortisol, ACTH and CRH were determined longitudinally from the plasma of 310 African American, Hispanic and non-Hispanic White women at 18–20, 24–26 and 30–32 weeks’ gestation. During pregnancy, African American women exhibited lower levels of cortisol than non-Hispanic women and higher levels of ACTH than Hispanic women. The trajectory of CRH increase also differed by ethnicity, with African Americans exhibiting the lowest levels both early and late in pregnancy. Higher levels of cortisol at 18–20 weeks were associated with higher levels of CRH at 30–32 weeks among the African American and Hispanic women, but not among non-Hispanic women. Ethnic differences persisted when adjusting statistically for sociodemographic and biomedical factors. The findings are consistent with the possibility that ethnic disparities in adverse birth outcomes may be due, in part, to differences in HPA axis and placental function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 28, Issue 6, June 2007, Pages 1155–1161
نویسندگان
, , , , ,