کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008617 1066434 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peripheral adrenomedullin inhibits gastric emptying through CGRP8–37-sensitive receptors and prostaglandins pathways in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Peripheral adrenomedullin inhibits gastric emptying through CGRP8–37-sensitive receptors and prostaglandins pathways in rats
چکیده انگلیسی

The effects of intravenous (iv) adrenomedullin (AM) on gastric emptying were investigated in conscious rats. AM induced a maximal 50% inhibition of gastric emptying at a dose of 1.2 nmol/kg. AM was about two-fold less potent than α-calcitonin gene-related peptide (α-CGRP), which induced a similar 50% maximal inhibition of gastric emptying at 0.6 nmol/kg. Delayed gastric emptying induced by i.v. AM and α-CGRP was prevented by peripheral injection of the selective CGRP1 antagonist, CGRP8–37, and by pretreatment with indomethacin, while not altered by blockade of the sympathetic nervous system with propranolol. These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP8–37-sensitive receptors, likely CGRP1 receptors, and the recruitment of prostaglandin-dependent mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 27, Issue 6, June 2006, Pages 1376–1382
نویسندگان
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