کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2008707 | 1066439 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina
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کلمات کلیدی
RT-PCRADNPActivity-dependent neuroprotective protein (ADNP)CRLRVPAC2Receptor activity modifying protein 1AT1AVPAC1RAMP1CGRPVIPGAPDHAng-2 - The-2sexual function - عملکرد جنسیreverse transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز رونویسی معکوسActivity-dependent neuroprotective protein - پروتئین محافظتی وابسته به فعالیتVasoactive intestinal polypeptide - پلیپپتید روده روغنیVasoactive intestinal peptide (VIP) - پپتید روده روغنی (VIP)Calcitonin gene-related peptide (CGRP) - پپتید مرتبط با ژن Calcitonin (CGRP)calcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونینGlyceraldehyde phosphate dehydrogenase - گلیسرالیدید فسفات دهیدروژنازcalcitonin receptor-like receptor - گیرنده ی گیرنده کلسایتونین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina](/preview/png/2008707.png)
چکیده انگلیسی
Vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and angiotensin 2 are key neuropeptides that innervate the sexual organs. For further understanding of neuropeptide involvement in female sexual function, we investigated peptide receptor mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) in the rat vagina and clitoris, and alteration during the shift from the proestrus to the estrus phase. VIP, angiotensin 2 and CGRP receptor subtypes transcripts were found to be expressed in the vagina and the clitoris. Significantly increased levels of angiotensin 2 and CGRP receptor subtypes transcripts were observed in the vagina as compared to the clitoris. Significant increases in the expression of the VIP receptor type 2 (VPAC2) mRNA and parallel increases in a novel VIP responsive gene, activity-dependent neuroprotective protein (ADNP) mRNA were detected in the rat vagina during the estrus phase. The expression pattern of neuropeptide receptors in the female sexual organs suggest an intimate involvement of the corresponding neuropeptides in female sexual function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 12, December 2005, Pages 2579-2584
Journal: Peptides - Volume 26, Issue 12, December 2005, Pages 2579-2584
نویسندگان
David Dangoor, Eliezer Giladi, Mati Fridkin, Illana Gozes,