کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2008771 1066444 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of novel hexapeptide agonists at the Xenopus laevis melanophore melanocortin receptor
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Identification of novel hexapeptide agonists at the Xenopus laevis melanophore melanocortin receptor
چکیده انگلیسی

We used a combinatorial chemical approach to identify novel agonists for the endogenous melanocortin receptor expressed in Xenopus laevis melanophores. A random one-bead one-compound hexapeptide library was screened to detect new molecules able to induce pigment dispersion in melanophores. Our approach led to the discovery of seven related novel peptides able to stimulate pigment dispersion with EC50 in the range of 0.1–10 μM. Their action was inhibited by the amphibian melanocortin receptor antagonist dWRL. These novel peptides share no significant sequence homology with known melanocortins. This study may aid in the understanding of the chemical interaction between the melanocortin receptors and their ligands.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 26, Issue 11, November 2005, Pages 2124–2128
نویسندگان
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