کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2010416 1066973 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimation of oxidative stress parameters in rats after simultaneous administration of rosuvastatin with antidepressants
ترجمه فارسی عنوان
برآورد پارامترهای استرس اکسیداتیو در موش بعد از تجویز همزمان روزوواستاتین با داروهای ضدافسردگی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundPatients commonly receive statin drugs for the primary or secondary prevention of cardiovascular events and also commonly receive antidepressant drugs for the treatment of depression. A many-year polypharmacotherapy can lead to increased side effects of these drugs. It may lead to an oxidation–reduction imbalance and the growth of a generation of reactive oxygen species (ROS) which may induce cellular dysfunctions.MethodsThe aim of this study was to assess oxidative stress parameters in the blood of rats after simultaneous administration of rosuvastatin (10 mg/kg) with paroxetine (10 mg/kg) or citalopram (10 mg/kg). The activity of glutathione peroxidase (GPX) was determined in whole blood, and the activity of glutathione reductase (GR) and the total antioxidant status (TAS) were determined in the serum.ResultsThe 14-day simultaneous administration of rosuvastatin with paroxetine or citalopram caused an increase in glutathione peroxidase and glutathione reductase activity and did not influence the level of the total antioxidant status. Rosuvastatin (10 mg/kg) or citalopram (10 mg/kg) administered alone to rats for 14 days did not affect the examined parameters. The 14-day application of paroxetine (10 mg/kg) significantly decreased a glutathione peroxidase activity, increased a glutathione reductase activity and did not affect the level of TAS.ConclusionsThe observed changes may indicate an increased activity of the enzyme system preventing oxidation, which appears to be the effect of the reaction on the severity of oxidative stress during the combined treatment with rosuvastatin and antidepressants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 68, Issue 1, February 2016, Pages 172–176
نویسندگان
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