کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2010837 | 1066990 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The effects of sphingosine-1-phosphate (S1P) on bronchial smooth muscle (BSM) contractility were investigated in naive mice. S1P had no effect on the basal tone of the isolated BSM tissues. However, in the presence of S1P(10-6 M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left. In contrast, the pretreatment with S1P had no effect on the contractions induced by high K+ depolarization. It is thus possible that S1P augments BSM contraction induced by the activation of G protein-coupled receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 63, Issue 2, March–April 2011, Pages 544–547
Journal: Pharmacological Reports - Volume 63, Issue 2, March–April 2011, Pages 544–547
نویسندگان
Yoshihiko Chiba, Hiroki Takeuchi, Hiroyasu Sakai, Miwa Misawa,