Endocannabinoid system protects against cryptogenic seizures

Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5–8 days. We hypothesize that an accumulation of microinjuries in the brain is responsible for these “spontaneous” seizures.