کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2011200 1066997 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Family-based study of brain-derived neurotrophic factor ( ΒDNF) gene polymorphism in alcohol dependence
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Family-based study of brain-derived neurotrophic factor ( ΒDNF) gene polymorphism in alcohol dependence
چکیده انگلیسی

Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related to the nerve growth factor family, which are responsible for the proliferation, survival and differentiation of neurons. BDNF is thought to be involved in the pathogenesis of bipolar disorder, schizophrenia, eating disorders and addiction. We hypothesize that a functionally relevant polymorphism of the ΒDNF gene promoter may be associated with the pathogenesis of alcohol dependence.We performed an association study of 141 families with alcohol dependence. One hundred and thirty-eight healthy control subjects were matched based on ethnicity and gender. An association between the ΒDNF Val66Met gene polymorphism and alcoholism was not found.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 62, Issue 5, September–October 2010, Pages 938–941
نویسندگان
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