کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2011201 | 1066997 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Dose-response relationship analysis of pregabalin doses and their antinociceptive effects in hot-plate test in mice Dose-response relationship analysis of pregabalin doses and their antinociceptive effects in hot-plate test in mice](/preview/png/2011201.png)
The aim of this study was to determine the analgesic effects of pregabalin (a third-generation antiepileptic drug) using the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate a dose-response relationship between logarithms of pregabalin doses and their resultant maximum possible antinociceptive effects (MPAE) using the hot-plate test in mice. From the linear equation of the dose-response relationship, doses of pregabalin that increased antinociceptive effects by 20%, 30%, 40%, and 50% were calculated and amounted to 9.33, 24.80, 65.93, and 175.26 mg/kg, respectively. In conclusion, pregabalin produces analgesic effects in a dose-dependent manner, as demonstrated using the hot-plate test in mice.
Journal: Pharmacological Reports - Volume 62, Issue 5, September–October 2010, Pages 942–948