کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2011576 | 1067010 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of the acute effect of leptin on the inhibition of glycogen catabolism by insulin in rat liver perfused in situ
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Investigation of the acute effect of leptin on the inhibition of glycogen catabolism by insulin in rat liver perfused in situ Investigation of the acute effect of leptin on the inhibition of glycogen catabolism by insulin in rat liver perfused in situ](/preview/png/2011576.png)
چکیده انگلیسی
Leptin, a cytokine secreted by adipose tissue, has been implicated in the insulin resistance associated with obesity. Here we examined the acute influence of leptin at physiological (10 ng/mL) and supraphysiological (50 ng/mL and 100 ng/mL) concentrations on the inhibition of glycogen catabolism promoted by insulin in rat liver perfusion experiments. Perfusion of the liver with insulin (20 μU/mL) decreased the activation of glucose production (p < 0.05) and glycogenolysis by cAMP (3 μM). However, the infusion of leptin, at concentrations similar to those found in non-obese (10 ng/mL), obese (50 ng/mL), and morbidly obese (100 ng/mL) individuals did not influence the acute inhibitory effect of insulin (20 μU/mL) on glucose production and glycogenolysis stimulated by cAMP(p > 0.05).We conclude that neither physiological nor supraphysiological concentrations of leptin directly influence the inhibition of glycogen catabolism promoted by insulin in rat liver perfused in situ.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 61, Issue 2, MarchâApril 2009, Pages 319-324
Journal: Pharmacological Reports - Volume 61, Issue 2, MarchâApril 2009, Pages 319-324
نویسندگان
Erica G. Mario, Eledir S. Leonardo, Bruna K. Bassoli, Priscila Cassolla, Glaucia R. Borba-Murad, Roberto B. Bazotte, Helenir M. De Souza,