کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2011899 1067018 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism
ترجمه فارسی عنوان
استرس اکسیداتیو به عنوان یک عامل علمی و یک هدف بالقوه درمان اختلالات روانپزشکی. قسمت 2. افسردگی، اضطراب، اسکیزوفرنی و اوتیسم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based on clinical trials and animal studies, in addition, we analyze the effects of drug-induced modulation of oxidative balance and explore pharmacotherapeutic strategies for oxidative stress reduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 67, Issue 3, June 2015, Pages 569–580
نویسندگان
, , , , , , , ,