کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2011981 | 1067021 | 2015 | 8 صفحه PDF | دانلود رایگان |
BackgroundInfluence of a relatively specific inhibitor cyclooxygenase (COX)-2, celecoxib, a relatively specific inhibitor of neuronal nitric oxide synthase (NOS), 7-Ni, and a relatively selective inhibitor of inducible NOS, L-NIL, on the action of a preferentially selective CB1 cannabinoid receptor agonist, Met-F-AEA and a selective CB2 cannabinoid receptor agonist, AM 1241 was investigated, in a streptozotocin (STZ)-induced neuropathy.MethodsStudies were performed on male Wistar rats. Changes in nociceptive thresholds were determined using mechanical stimuli – the modification of the classic paw withdrawal test described by Randall-Selitto. Diabetes was induced by a single administration of STZ.ResultsIn a diabetic neuropathic pain model, pretreatment with celecoxib, L-NIL and 7-Ni, significantly increased the antihyperalgesic activity of both Met-F-AEA and AM 1241.ConclusionsThe results of this study seemed to indicate that the interaction between cannabinoid, COX-2 and NOS(s) systems might exist. Concomitant administration of small doses of CB1 and/or CB2 receptor agonists and COX-2 or NOS inhibitors can be effective in the alleviation of diabetic neuropathic pain.
Journal: Pharmacological Reports - Volume 67, Issue 2, April 2015, Pages 209–216