کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2012197 | 1067027 | 2014 | 5 صفحه PDF | دانلود رایگان |
BackgroundThe goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality.MethodsSubjects with established coronary heart disease (CHD) (n = 1345, mean age 63.2 ± 9.2 years) were included.ResultsNon-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00–4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02–1.47) and non-nighttime antihypertensive drug administration (HR 1.13, 95% CI 1.01–1.45) were predictors of all-cause mortality.ConclusionsThe non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime.
Journal: Pharmacological Reports - Volume 66, Issue 3, June 2014, Pages 448–452