The number of regulatory Foxp3+ T-cells in different stages of malignant transformation of large intestinal polyps

An increase in the number of Tregs in the lymphocytic infiltrate of large intestinal polyps is interestingly already observed at early stages of carcinogenesis. Proportions of various T-cell subpopulations in the infiltrate vary considerably depending on the degree of dysplasia, especially in the case of invasive colorectal cancer.