کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039121 1073027 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction
ترجمه فارسی عنوان
سلول های غول پیکر چند هسته ای برای فاگوسیتوز با تکثیر و تخریب هدف بزرگ
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• MGCs are specialized for phagocytosis of large and complement-opsonized particles
• MGCs show extensive membrane ruffles containing pre-activated complement receptor 3
• Membrane ruffles provide excess membrane for ingestion of large materials
• MGCs eliminate systemic amyloid deposits after immunotherapeutic targeting

SummaryMultinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute to the removal of debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large and complement-opsonized materials more effectively than their unfused M2 macrophage precursors. MGC expression of complement receptor 4 (CR4) was increased, but it functioned primarily as an adhesion integrin. In contrast, although expression of CR3 was not increased, it became functionally activated during fusion and was located on the extensive membrane ruffles created by excess plasma membrane arising from macrophage fusion. The combination of increased membrane area and activated CR3 specifically equips MGCs to engulf large complement-coated targets. Moreover, we demonstrate these features in vivo in the recently described complement-dependent therapeutic elimination of systemic amyloid deposits by MGCs. MGCs are evidently more than the sum of their macrophage parts.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 9, 1 December 2015, Pages 1937–1948
نویسندگان
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