کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039227 1073037 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury
ترجمه فارسی عنوان
نورون های پرولاوبومن سوراخ پشتی دروازه های نگهدارنده درد ناشی از لمس پس از آسیب عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Parvalbumin (PV) neurons of the dorsal horn synapse onto PKCγ excitatory neurons
• After nerve injury, many PV-PKCγ synapses are lost and touch stimuli become painful
• Specific activation of PV neurons after nerve injury alleviates mechanical pain

SummaryNeuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal horn of the spinal cord is a major contributor to neuropathic pain, the molecular and cellular mechanisms underlying this disinhibition are unclear. Here, we combined pharmacogenetic activation and selective ablation approaches in mice to define the contribution of spinal cord parvalbumin (PV)-expressing inhibitory interneurons in naive and neuropathic pain conditions. Ablating PV neurons in naive mice produce neuropathic pain-like mechanical allodynia via disinhibition of PKCγ excitatory interneurons. Conversely, activating PV neurons in nerve-injured mice alleviates mechanical hypersensitivity. These findings indicate that PV interneurons are modality-specific filters that gate mechanical but not thermal inputs to the dorsal horn and that increasing PV interneuron activity can ameliorate the mechanical hypersensitivity that develops following nerve injury.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 6, 10 November 2015, Pages 1246–1257
نویسندگان
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