کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039229 1073037 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rhythmic Working Memory Activation in the Human Hippocampus
ترجمه فارسی عنوان
فعال سازی حافظه کاری ریتمیک در هیپوکامپ انسان
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Working memory depends on rhythmic fluctuations in the human hippocampus
• Periods of memory activation are interleaved with periods of constant power levels
• Fluctuations between these two modes of processing are organized by delta rhythm
• A hierarchy of oscillations predicts successful performance and individual capacity

SummaryWorking memory (WM) maintenance is assumed to rely on a single sustained process throughout the entire maintenance period. This assumption, although fundamental, has never been tested. We used intracranial electroencephalography (EEG) recordings from the human hippocampus in two independent experiments to investigate the neural dynamics underlying WM maintenance. We observed periodic fluctuations between two different oscillatory regimes: Periods of “memory activation” were reflected by load-dependent alpha power reductions and lower levels of cross-frequency coupling (CFC). They occurred interleaved with periods characterized by load-independent high levels of alpha power and CFC. During memory activation periods, a relevant CFC parameter (load-dependent changes of the peak modulated frequency) correlated with individual WM capacity. Fluctuations between these two periods predicted successful performance and were locked to the phase of endogenous delta oscillations. These results show that hippocampal maintenance is a dynamic rather than constant process and depends critically on a hierarchy of oscillations.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 6, 10 November 2015, Pages 1272–1282
نویسندگان
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