کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039307 1073047 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Slow-γ Rhythms Coordinate Cingulate Cortical Responses to Hippocampal Sharp-Wave Ripples during Wakefulness
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Slow-γ Rhythms Coordinate Cingulate Cortical Responses to Hippocampal Sharp-Wave Ripples during Wakefulness
چکیده انگلیسی


• Neurons in cingulate cortex (CG) respond to hippocampal SWR in alert rats
• Cingulate and hippocampal neural activity exhibits a SWR-triggered increase in slow-γ coordination
• SWR modulation of CG single units correlates with their phase locking to the hippocampal slow-γ

SummaryBehavioral changes in response to reward require monitoring past behavior relative to present outcomes. This is thought to involve a fine coordination between the hippocampus (HIPP), which stores and replays memories of past events, and cortical regions such as cingulate cortex, responsible for behavioral planning. Sharp-wave ripple (SWR)-mediated memory replay in the HIPP of awake rodents contributes to learning, but cortical responses to hippocampal SWR during wakefulness are not known. We now show that in rats, during quiet-wakefulness, cingulate neurons exhibit significant responses to SWR, as well as increased modulation by the accompanying hippocampal local field potential slow-γ oscillation, a rhythm associated with intra-hippocampal information processing. The magnitude of cingulate neurons’ responses to SWR is significantly correlated with the degree of their modulation by HIPP slow-γ. We hypothesize that during pauses cingulate neurons transiently access episodic information concerning previous choices, replayed by HIPP SWR, to evaluate past trajectories in light of their outcome.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 7, 17 November 2015, Pages 1327–1335
نویسندگان
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