کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039311 1073047 2015 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways
ترجمه فارسی عنوان
دوقلو باعث حفظ و تمایز سلول های بنیادی ژرمین شده از طریق مدولاسیون مسیرهای چندگانه می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Twin, a deadenylase CCR4/NOT subunit, intrinsically maintains stem cell self-renewal
• Twin sustains E-cadherin expression and prevents DNA damage in stem cells
• Twin promotes Bam-dependent stem cell progeny differentiation

SummaryThe central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 homolog Twin is required intrinsically to promote both GSC self-renewal and progeny differentiation. Twin/CCR4 is one of the two catalytic subunits in the highly conserved CCR4-NOT mRNA deadenylase complex. Twin works within the CCR4-NOT complex to intrinsically maintain GSC self-renewal, at least partly by sustaining E-cadherin-mediated GSC-niche interaction and preventing transposable element-induced DNA damage. It promotes GSC progeny differentiation by forming protein complexes with differentiation factors Bam and Bgcn independently of other CCR4-NOT components. Interestingly, Bam can competitively inhibit the association of Twin with Pop2 in the CCR4-NOT complex. Therefore, this study demonstrates that Twin has important intrinsic roles in promoting GSC self-renewal and progeny differentiation by functioning in different protein complexes.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 7, 17 November 2015, Pages 1366–1379
نویسندگان
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