کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039474 1073061 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations
ترجمه فارسی عنوان
برنامه های سندرم متابولیک مادران اختلال های میتوکندریایی از طریق تغییرات ژرمین در سه نسل
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Inbred mice fed a high-fat/high-sucrose (HF/HS) diet develop metabolic syndrome
• F1, F2, and F3 offspring from HF/HS-fed dams develop mitochondrial dysfunction
• Proteins involved in mitochondrial dynamics and ETC are misexpressed in F1–F3 pups
• Mitochondrial changes are seen in F1–F2 oocytes, suggesting germline transmission

SummaryMaternal obesity impairs offspring health, but the responsible mechanisms are not fully established. To address this question, we fed female mice a high-fat/high-sugar diet from before conception until weaning and then followed the outcomes in the next three generations of offspring, all fed a control diet. We observed that female offspring born to obese mothers had impaired peripheral insulin signaling that was associated with mitochondrial dysfunction and altered mitochondrial dynamic and complex proteins in skeletal muscle. This mitochondrial phenotype persisted through the female germline and was passed down to the second and third generations. Our results indicate that maternal programming of metabolic disease can be passed through the female germline and that the transfer of aberrant oocyte mitochondria to subsequent generations may contribute to the increased risk for developing insulin resistance.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 1, 28 June 2016, Pages 1–8
نویسندگان
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