کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039492 1073061 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Dual-Sensing Receptor Confers Robust Cellular Homeostasis
ترجمه فارسی عنوان
یک گیرنده دوگانه حسگر را تنظیم می کند هوموستاز سلول قوی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• The bifunctional receptor KdpD senses extra- and intracellular K+
• Kinase and phosphatase activities are regulated by K+
• The dual-sensing strategy is superior under fluctuating conditions

SummaryCells have evolved diverse mechanisms that maintain intracellular homeostasis in fluctuating environments. In bacteria, control is often exerted by bifunctional receptors acting as both kinase and phosphatase to regulate gene expression, a design known to provide robustness against noise. Yet how such antagonistic enzymatic activities are balanced as a function of environmental change remains poorly understood. We find that the bifunctional receptor that regulates K+ uptake in Escherichia coli is a dual sensor, which modulates its autokinase and phosphatase activities in response to both extracellular and intracellular K+ concentration. Using mathematical modeling, we show that dual sensing is a superior strategy for ensuring homeostasis when both the supply of and demand for a limiting resource fluctuate. By engineering standards, this molecular control system displays a strikingly high degree of functional integration, providing a reference for the vast numbers of receptors for which the sensing strategy remains elusive.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 1, 28 June 2016, Pages 213–221
نویسندگان
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