کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039683 1073075 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
ترجمه فارسی عنوان
رقابت سلولی جایگزین قلب فنوتیپی خنثی در قلب پستانداران را تقویت می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Cardiomyocytes are sensitive to Myc-induced competition in development and adult life
• Cardiomyocyte competition is driven by short-range interactions leading to cell death
• Cardiomyocyte replacement by cell competition is phenotypically silent

SummaryHeterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardiomyocyte-replacement strategy.

Graphical AbstractFigure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 8, Issue 6, 25 September 2014, Pages 1741–1751
نویسندگان
, , , ,