کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039713 1073076 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted Delivery of Immunomodulators to Lymph Nodes
ترجمه فارسی عنوان
تحویل هدفمند از ایمونومولاتورها به گره های لنفاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• The MECA79 antibody binds peripheral lymph node addressin (PNAd)
• Tacrolimus-loaded microparticles coated with MECA79 target lymph nodes
• Microparticles accumulate in draining lymph nodes after intravenous delivery
• Targeted delivery of tacrolimus prolonged allograft survival

SummaryActive-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node addressin molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration, MECA79-bearing particles showed marked accumulation in the draining lymph nodes of transplanted animals. Using an allograft heart transplant model, we show that targeted lymph node delivery of microparticles containing tacrolimus can prolong heart allograft survival with negligible changes in tacrolimus serum level. Using MECA79 conjugation, we have demonstrated targeted delivery of tacrolimus to the lymph nodes following systemic administration, with the capacity for immune modulation in vivo.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 6, 10 May 2016, Pages 1202–1213
نویسندگان
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