کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2039835 1073085 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
ترجمه فارسی عنوان
واکسیناسیون با سلول های سرطان نابجا باعث ایجاد ایمنی ضد تومور کارآمد می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Necroptotic cancer cells release DAMPs and induce dendritic cell maturation in vitro
• Cross-priming of T cells was induced by necroptotic cancer cells in vivo
• Necroptotic cancer cells promote the tumor antigen-specific production of IFN-γ ex vivo
• Prophylactic injection of necroptotic cancer cells leads to an anti-tumor vaccination

SummarySuccessful immunogenic apoptosis in experimental cancer therapy depends on the induction of strong host anti-tumor responses. Given that tumors are often resistant to apoptosis, it is important to identify alternative molecular mechanisms that elicit immunogenic cell death. We have developed a genetic model in which direct dimerization of FADD combined with inducible expression of RIPK3 promotes necroptosis. We report that necroptotic cancer cells release damage-associated molecular patterns and promote maturation of dendritic cells, the cross-priming of cytotoxic T cells, and the production of IFN-γ in response to tumor antigen stimulation. Using both FADD-dependent and FADD-independent RIPK3 induction systems, we demonstrate the efficient vaccination potential of immunogenic necroptotic cells. Our study broadens the current concept of immunogenic cell death and opens doors for the development of new strategies in cancer therapy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 2, 12 April 2016, Pages 274–287
نویسندگان
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