کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040116 1073098 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability
ترجمه فارسی عنوان
یادآوری ضعف حافظه موقعیتی به دنبال انسداد شبیه سازی از ثبات مکان
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Transgenic model for spatiotemporal control of neuronal silencing via systemic ligand
• Acute silencing of entorhinal cortex causes global disruption of CA1 spatial tuning
• Concomitant with CA1 remapping, entorhinal silencing degrades spatial recall
• Both place field stability and spatial memory require the same ongoing cortical input

SummaryThe neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocampus. When entorhinal input to the perforant path was acutely silenced, hippocampal firing patterns became destabilized and underwent extensive remapping. We also found that spatial memory acquired prior to neural silencing was impaired by loss of input through the perforant path. Together, our experiments show that manipulation of entorhinal activity destabilizes spatial coding and disrupts spatial memory. Moreover, we introduce a chemogenetic model for non-invasive neuronal silencing that offers multiple advantages over existing strategies in this setting.

Graphical AbstractFigure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 3, 19 July 2016, Pages 793–804
نویسندگان
, , , , , , , , , , , ,