کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040129 1073099 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life
ترجمه فارسی عنوان
لپتین کنترل پارازایمپاتیک پانکراس را در طول زندگی جنینی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Autonomic innervation of pancreatic islets develops during mid-gestation in mice
• Leptin is required for normal parasympathetic innervation of pancreatic β cells
• Acute leptin injections in embryos cause lifelong disturbances in glucose homeostasis
• Leptin acts directly on the hindbrain to modulate cholinergic axon growth

SummaryThe autonomic nervous system plays a critical role in glucose metabolism through both its sympathetic and parasympathetic branches, but the mechanisms that underlie the development of the autonomic innervation of the pancreas remain poorly understood. Here, we report that cholinergic innervation of pancreatic islets develops during mid-gestation under the influence of leptin. Leptin-deficient mice display a greater cholinergic innervation of pancreatic islets beginning in embryonic life, and this increase persists into adulthood. Remarkably, a single intracerebroventricular injection of leptin in embryos caused a permanent reduction in parasympathetic innervation of pancreatic β cells and long-term impairments in glucose homeostasis. These developmental effects of leptin involve a direct inhibitory effect on the outgrowth of preganglionic axons from the hindbrain. These studies reveal an unanticipated regulatory role of leptin on the parasympathetic nervous system during embryonic development and may have important implications for our understanding of the early mechanisms that contribute to diabetes.

Graphical AbstractFigure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 1, 5 April 2016, Pages 36–44
نویسندگان
, , ,