کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040226 1073103 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling
ترجمه فارسی عنوان
مقررات وابسته به وابستگی رشد سرطان پانکراس و آنژیوژنز توسط نشانه گذاری خارپشت
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• HH coreceptors are expressed in adult pancreas and upregulated in pancreatic cancer
• Stromal deletion of Gas1 and Boc reduces HH signaling but promotes tumorigenesis
• Complete blockade of HH signaling is required to inhibit pancreatic tumor growth
• Reduced HH signaling promotes tumor growth through increased angiogenesis

SummaryPancreatic cancer, a hypovascular and highly desmoplastic cancer, is characterized by tumor expression of Hedgehog (HH) ligands that signal to fibroblasts in the surrounding stroma that in turn promote tumor survival and growth. However, the mechanisms and consequences of stromal HH pathway activation are not well understood. Here, we show that the HH coreceptors GAS1, BOC, and CDON are expressed in cancer-associated fibroblasts. Deletion of two coreceptors (Gas1 and Boc) in fibroblasts reduces HH responsiveness. Strikingly, these fibroblasts promote greater tumor growth in vivo that correlates with increased tumor-associated vascularity. In contrast, deletion of all three coreceptors (Gas1, Boc, and Cdon) results in the near complete abrogation of HH signaling and a corresponding failure to promote tumorigenesis and angiogenesis. Collectively, these data identify a role for HH dosage in pancreatic cancer promotion and may explain the clinical failure of HH pathway blockade as a therapeutic approach in pancreatic cancer.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 9, Issue 2, 23 October 2014, Pages 484–494
نویسندگان
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