کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040356 1073107 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of Host-like Peptide Motifs in Viral Proteins Is a Prevalent Strategy in Host-Virus Interactions
ترجمه فارسی عنوان
استفاده از موتیف های پپتید مانند ویروس پروتئین ویروسی یک استراتژی شایع در تعاملات ویروس است
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Viruses exploit molecular mimicry through host-like peptide motifs for replication
• Motifs are used by different viruses to different extents
• Rapid evolution of viral peptide motifs may rewire host-virus interaction networks
• Co-occurring motifs facilitate combinatorial regulation of host-virus interactions

SummaryViruses interact extensively with host proteins, but the mechanisms controlling these interactions are not well understood. We present a comprehensive analysis of eukaryotic linear motifs (ELMs) in 2,208 viral genomes and reveal that viruses exploit molecular mimicry of host-like ELMs to possibly assist in host-virus interactions. Using a statistical genomics approach, we identify a large number of potentially functional ELMs and observe that the occurrence of ELMs is often evolutionarily conserved but not uniform across virus families. Some viral proteins contain multiple types of ELMs, in striking similarity to complex regulatory modules in host proteins, suggesting that ELMs may act combinatorially to assist viral replication. Furthermore, a simple evolutionary model suggests that the inherent structural simplicity of ELMs often enables them to tolerate mutations and evolve quickly. Our findings suggest that ELMs may allow fast rewiring of host-virus interactions, which likely assists rapid viral evolution and adaptation to diverse environments.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 7, Issue 5, 12 June 2014, Pages 1729–1739
نویسندگان
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