کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040739 1073127 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Defining Resistance and Tolerance to Cancer
ترجمه فارسی عنوان
تعریف مقاومت و تحمل به سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• We developed a framework for differentiating resistance and tolerance to cancer
• Cancer kills flies in a dose-dependent manner
• Natural variation affects cancer resistance
• We identified a fly line with reduced resistance to cancer

SummaryThere are two ways to maintain fitness in the face of infection: resistance is a host’s ability to reduce microbe load and disease tolerance is the ability of the host to endure the negative health effects of infection. Resistance and disease tolerance should be applicable to any insult to the host and have been explored in depth with regards to infection but have not been examined in the context of cancer. Here, we establish a framework for measuring and separating resistance and disease tolerance to cancer in Drosophila melanogaster. We plot a disease tolerance curve to cancer in wild-type flies and then compare this to natural variants, identifying a line with reduced cancer resistance. Quantitation of these two traits opens an additional dimension for analysis of cancer biology.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 5, 3 November 2015, Pages 884–887
نویسندگان
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