کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2040918 1073136 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of Autocrine Signaling in Subsets of Sympathetic Neurons Has Regional Effects on Tissue Innervation
ترجمه فارسی عنوان
مقررات سیگنالینگ اتوکرین در زیرونهای عصبی سمپاتیک دارای تأثیرات منطقه ای بر عفونت بافتی است
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• CD40/CD40L autocrine signaling enhances NGF-promoted sympathetic axon growth
• NGF negatively regulates CD40 and CD40L levels in developing sympathetic neurons
• Accordingly, CD40/CD40L signaling only enhances axon growth at low levels of NGF
• Innervation of tissues expressing low NGF levels is disrupted in CD40 knockout mice

SummaryThe regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconcile autocrine signaling with the idea that targets control their innervation. Here, we report that an autocrine signaling loop in developing mouse sympathetic neurons involving CD40L (TNFSF5) and CD40 (TNFRSF5) selectively enhances NGF-promoted axon growth and branching, but not survival, via CD40L reverse signaling. Because NGF negatively regulates CD40L and CD40 expression, this signaling loop operates only in neurons exposed to low levels of NGF. Consequently, the sympathetic innervation density of tissues expressing low NGF is significantly reduced in CD40-deficient mice, whereas the innervation density of tissues expressing high levels of NGF is unaffected. Our findings reveal how differential regulation of autocrine signaling in neurons has region-specific effects on axon growth and tissue innervation.

Graphical AbstractFigure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 10, Issue 9, 10 March 2015, Pages 1443–1449
نویسندگان
, , , ,