کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2041058 1073143 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action
ترجمه فارسی عنوان
تعامل متابولیکی بین استروسیت ها و نورون ها را تنظیم می کند که فعالیت اندوکانبینیو را تنظیم می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Genetic mouse models reveal cellular specificity of 2-AG metabolism
• Astrocytes and neurons collaborate to terminate endocannabinoid signaling
• Coordinated astrocytic-neuronal metabolism protects against CB1R desensitization
• Astrocytes couple 2-AG hydrolysis to neuroinflammatory prostaglandin production

SummaryThe endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG signaling is terminated by enzymatic hydrolysis—a reaction that is principally performed by monoacylglycerol lipase (MAGL). MAGL is broadly expressed throughout the nervous system, and the contributions of different brain cell types to the regulation of 2-AG activity in vivo remain poorly understood. Here, we genetically dissect the cellular anatomy of MAGL-mediated 2-AG metabolism in the brain and show that neurons and astrocytes coordinately regulate 2-AG content and endocannabinoid-dependent forms of synaptic plasticity and behavior. We also find that astrocytic MAGL is mainly responsible for converting 2-AG to neuroinflammatory prostaglandins via a mechanism that may involve transcellular shuttling of lipid substrates. Astrocytic-neuronal interplay thus provides distributed oversight of 2-AG metabolism and function and, through doing so, protects the nervous system from excessive CB1 receptor activation and promotes endocannabinoid crosstalk with other lipid transmitter systems.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 12, Issue 5, 4 August 2015, Pages 798–808
نویسندگان
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