کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2041374 1073158 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Host Actin Polymerization Tunes the Cell Division Cycle of an Intracellular Pathogen
ترجمه فارسی عنوان
پلیمریزاسیون مهار آتیک سلول بخش سلول را ایجاد می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Division is faster and non-dividing elongation is slower when Lm are intracellular
• Actin polymerization rebalances Lm cell division cycle
• Cell division cycle rebalancing increases Lm propensity to form actin tails

SummaryGrowth and division are two of the most fundamental capabilities of a bacterial cell. While they are well described for model organisms growing in broth culture, very little is known about the cell division cycle of bacteria replicating in more complex environments. Using a D-alanine reporter strategy, we found that intracellular Listeria monocytogenes (Lm) spend a smaller proportion of their cell cycle dividing compared to Lm growing in broth culture. This alteration to the cell division cycle is independent of bacterial doubling time. Instead, polymerization of host-derived actin at the bacterial cell surface extends the non-dividing elongation period and compresses the division period. By decreasing the relative proportion of dividing Lm, actin polymerization biases the population toward cells with the highest propensity to form actin tails. Thus, there is a positive-feedback loop between the Lm cell division cycle and a physical interaction with the host cytoskeleton.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 11, Issue 4, 28 April 2015, Pages 499–507
نویسندگان
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