کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2041449 1073161 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology
ترجمه فارسی عنوان
تجزیه و تحلیل بیان ژن-بیان ژن در پایگاه داده در موش های ترانس ژنیک در طول آسیب شناسی آمیلوئید یا تاو
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• Gene expression in WT and five mouse dementia models; four ages; three brain regions
• Validation of mouse models versus human genome data and network analysis
• In Aβ mice, plaques show 1:1 correlation with immune gene expression; all ages
• In old TAU mice, changes in immune and synaptic gene expression correlate with tangles

SummaryWe provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of “amyloid” transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and “TAU” transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles. Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex. The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice. The cortical network of TAU mice was entirely different with more hub genes and few in common with the other networks, suggesting reasons for specificity of cortical dysfunction in FTDP17. This Resource opens up many areas for investigation. All data are available and searchable at http://www.mouseac.org.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 10, Issue 4, 3 February 2015, Pages 633–644
نویسندگان
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