Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

SummaryThe generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.

Graphical AbstractFigure optionsDownload as PowerPoint slideHighlights
► Autologous iPSC-derived neural progenitors survive in the monkey brain for 6 months
► Grafted cells differentiate into neurons, astrocytes, and oligodendrocytes
► Autologous transplantation elicits minimal immune and glial response