A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

► Monoacylglycerol lipase (MAGL) is a major contributor to brain arachidonic acid pools ► MAGL mutation decreases neuroinflammation and amyloid β in Alzheimer's disease mouse ► MAGL blockade recapitulates brain prostaglandin and cytokine-lowering effects ► MAGL inhibitors may be a next-generation strategy for combating Alzheimer's disease