کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2062396 | 1076603 | 2015 | 6 صفحه PDF | دانلود رایگان |
Carnitine is an important factor in the initiation of progressive sperm motility and end stage of sperm maturation. The compound is transported by an organic cation/carnitine transporter (OCTN2), which is expressed in the male reproductive system. OCTN2 is encoded by SLC22A5 gene with proven −207C>G functional polymorphism. The aim of the case–control study was to investigate a potential association between the −207C>G SLC22A5 polymorphism and male infertility. The −207C>G SLC22A5 polymorphism was determined by means of TaqMan assay in 206 infertile Caucasian males and 256 ethnically matched controls. Besides genotyping study, sperm mitochondrial function was assessed using NADH-dependent NBT assay. The distribution of SLC22A5 genotypes in infertile men was as follows: CC – 29.6%, CG – 53.9%, GG – 16.5% and in fertile men: CC – 32.0%, CG – 50.0%, GG – 18.0%, and was comparable in both evaluated groups. Likewise, the studied polymorphism did not affect sperm mitochondrial function. The results of the current study demonstrated that −207C>G polymorphism of the SLC22A5 gene is not associated with male infertility.
Journal: Reproductive Biology - Volume 15, Issue 3, September 2015, Pages 178–183