کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2065116 1076905 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Palytoxin: Membrane mechanisms of action
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Palytoxin: Membrane mechanisms of action
چکیده انگلیسی

Palytoxin is a marine toxin originally isolated from the zoantharians of the genus Palythoa, but now is found in marine organisms ranging from dinoflagellates to fishes. With a MW of 2680, it is one of the largest nonpolymeric natural products ever found. Its complex structure has been elucidated and total synthesis has been achieved. With an LD50 of 25 ng/kg for rabbits (the most sensitive species), it is one of the most lethal marine toxins. It binds to the Na,K-ATPase specifically with a KD of 20 pM. It has a unique action on the Na,K-ATPase, converting the pump into an ion channel and resulting in K+ efflux, Na+ influx and membrane depolarization. As a result palytoxin causes a wide spectrum of secondary pharmacological actions. By acting like a key to unlock the internal structure of the Na,K-ATPase, palytoxin holds promise as a useful tool for investigation of the pump molecule.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 54, Issue 8, 15 December 2009, Pages 1183–1189
نویسندگان
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