کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2066103 1076966 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
First evidence of spirolides in Spanish shellfish
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
First evidence of spirolides in Spanish shellfish
چکیده انگلیسی

During the months of November and December 2005, a harmful algal bloom in the northwestern region of Spain caused the accumulation of different algal toxins in several types of shellfish. Many of the shellfish were contaminated at levels above European regulatory limit, presenting serious risks for human health. The analysis of mussels sampled in the affected areas to search for lipophilic toxins, using liquid chromatography tandem mass spectrometry (LC-MS/MS), showed the presence of free okadaic acid (OA) and dinophysistoxin-2 (DTX-2) as well as esters of these toxins. The results also revealed the presence of minor amounts of 13-desmethyl spirolide C (SPX-1) in the analysed samples, although this toxin has never been reported before in Spain. The combination of different MS modes of operation, just as enhanced MS (EMS) and MS3 experiments, allowed to confirm the first occurrence of spirolides in Spanish shellfish.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 48, Issue 8, 15 December 2006, Pages 1068–1074
نویسندگان
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