کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093877 1401346 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1
چکیده انگلیسی


• miR-29a promotes VSMC differentiation from stem cells.
• miR-29a suppresses YY1, a negative regulator of VSMC differentiation from stem cells.
• YY1 suppression may have implications in the treatment of cardiovascular disease.

MicroRNA-29a (miR-29a) has been extensively studied in tumor biology and fibrotic diseases, but little is known about its functional roles in vascular smooth muscle cell (VSMC) differentiation from embryonic stem cells (ESCs). Using well-established VSMC differentiation models, we have observed that miR-29a induces VSMC differentiation from mouse ESCs by negatively regulating YY1, a transcription factor that inhibits muscle cell differentiation and muscle-specific gene expression. Moreover, gene expression levels of three VSMC specific transcriptional factors were up-regulated by miR-29a over-expression, but down-regulated by miR-29a inhibition or YY1 over-expression. Taken together, our data demonstrate that miR-29a and its target gene, YY1, play a regulatory role in VSMC differentiation from ESCs in vitro and in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 17, Issue 2, September 2016, Pages 277–284
نویسندگان
, , , , , , , ,