کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2094420 | 1082016 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cerebellar heterokaryon formation increases with age and after irradiation Cerebellar heterokaryon formation increases with age and after irradiation](/preview/png/2094420.png)
Hematopoietic cells have been demonstrated to survive in many nonhematopoietic tissues after transplantation. Apparent “bone marrow-derived” cerebellar Purkinje cells in fact result from fusion events and it has been suggested that fusion may be a natural physiological phenomenon to rescue dysfunctioning cells. Here, we show that fusion of transplanted bone marrow cells with resident Purkinje cells is age-dependent and is strongly enhanced when Purkinje cells are damaged by high-dose irradiation. In addition, Purkinje heterokaryons occur in increased frequencies in the cerebellum of normal, unperturbed, aged mice compared to young animals. Our data suggest that age- and/or irradiation-induced dysfunctioning of Purkinje cells in the cerebellum is required for cell fusion.
Journal: Stem Cell Research - Volume 1, Issue 2, June 2008, Pages 150–154